UTILITY OF FEV1/FEV6 FOR AIRWAY OBSTRUCTION DIAGNOSIS IN DIFFERENT GENDER AND RACE

TOPIC: Obstructive Lung Diseases TYPE: Original Investigations PURPOSE: Due to the difficulty of forced vital capacity (FVC) maneuver, Forced expiratory volume in one second (FEV1)/Forced six seconds (FEV6); (FEV1/FEV6) has been proposed as alternative value for obstructive lung detection. We aim compare sensitivity and specificity FEV1/FEV6 among different gender race. METHODS: Retrospective data patients who underwent spirometry a pulmonary function laboratory community clinic from February 2018 October 2020 was utilized. The < 73 % are used cut-off airway pattern compared with gold standard post-bronchodilator FEV1/FVC 70%. RESULTS: Of 1747 (46.3% male, mean age 67 years ), 30.6% had defining by Thirty-five percent defect area under receiver operating characteristic curve (AUROC) 0.998 (95% CI 0.997-0.999, 94.06%, 99.63%. Male female comparable AUROC 0.9976 0.996-0.999) vs. 0.9987 (95%CI 0.9975-0.9999), (93.96 94.13%) (99.64 99.61%). Our were Caucasian (57.2%), Hispanic (40.7%), African American (2.1%). In group, 0.9979 0.9965-0.9999), 92.11, 99.53%. 0.9981 0.9966-0.9997), 95.72, 100.00%. 0.9891 0.9678-1.0000), 92.00, CONCLUSIONS: showed high diagnosing both genders. Further studies diverse populations needed confirm result races. CLINICAL IMPLICATIONS: may substitute diagnose performing FVC. DISCLOSURES: No relevant relationships Mohammed Ali, source=Web Response Pattharawin Pattharanitima, Shyamsunder Subramanian, Salim Surani, Pahnwat Taweesedt,